RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development
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چکیده
منابع مشابه
RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development.
Cytochromes P450 (P450s) are a superfamily of enzymes that have critical functions in liver to catalyze the biotransformation of numerous drugs. However, the functions of most P450s are not mature at birth, which can markedly affect the metabolism of drugs in newborns. Therefore, characterization of the developmental profiles and regulatory mechanisms of P450 expression is needed for more ratio...
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Whole-genome transcriptome measurements are pivotal for characterizing molecular mechanisms of chemicals and predicting toxic classes, such as genotoxicity and carcinogenicity, from in vitro and in vivo assays. In recent years, deep sequencing technologies have been developed that hold the promise of measuring the transcriptome in a more complete and unbiased manner than DNA microarrays. Here, ...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2019
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2019.01.017